Prof. Dr. med. Dimitra Kiritsi

Our work focuses on characterizing the causes and pathogenetic mechanisms of genetic and acquired causes of skin fragility. We focus on gaining a better understanding of how skin fragility disorders arise and especially the connection to inflammation, the immune system and the development of skin carcinomas. A special interest exists on the genetic skin disorder epidermolysis bullosa, for which we are investigating disease modifiers and how they change disease progression and attempt to identify biomarkers. Using patient material and animal models we are examining the therapeutic potential of novel treatment options, e.g. mesenchymal stem cells or ��revertant mosaic�� cells. In terms of autoimmune skin fragility disorders, our group is involved in the characterization of rare subtypes, enabling establishment of diagnostic algorithms and therapeutic regimes. Further, pathogenetic causes of poor wound healing are being investigated, both in genetic models, but also using cells of individuals with common causes of leg ulcers. By leading several clinical trials, direct transfer from the work on the bench to the bedside is facilitated.

Our group combines clinical expertise and laboratory research with the goal of disclosing pathogenetic disease mechanisms resulting in skin fragility, promoting the understanding of disease variability, and improving the diagnostic and therapeutic possibilities for skin fragility diseases, either genetic or acquired. Our research is funded by the German Research Foundation (CRC1160, CRC1479, other DFG grants), EB Research Partnership (USA), the Fritz-Thyssen Foundation, the Berta-Ottenstein programme for Advanced Clinician Scientists, as well as the industry. In addition, Prof. Dr. Kiritsis work has received several awards and scholarships.